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L6292 Sigma-Aldrich

Lisinopril

≥98% (HPLC)

Synonym: (S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dihydrate, MK-521

  • CAS Number 83915-83-7

  • Empirical Formula (Hill Notation) C21H31O5N3 · 2H2O

  • Molecular Weight 441.52

  •  MDL number MFCD01698825

  •  PubChem Substance ID 329817636

  •  NACRES NA.32

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Merck & Co., Inc., Kenilworth,NJ
Quality Level   100
assay   ≥98% (HPLC)
form   solid
color   white
solubility   H2O: ≥10 mg/mL
  DMSO: ~6.5 mg/mL (with heating and sonicating)
storage temp.   2-8°C
SMILES string   [H]O[H].[H]O[H].NCCCC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O
InChI   1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
InChI key   CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
Gene Information   human ... ACE(1636)

Description

Application

Lisinopril has been used to study the antifibrotic effect in duchenne muscular dystrophy mice. It has been used to study the changes in renal-structure and -function in TGR(mRen2)27 (transgenic rat harboring the murine Ren-2 gene) rats upon long term darbepoetin α treatment.

Packaging

100, 250 mg in glass bottle

Biochem/physiol Actions

Angiotensin converting enzyme (ACE) inhibitor.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Target organs 
Kidney
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
TW3589990
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

Peer-Reviewed Papers
15

References

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