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L6914 SAFC

L-Leucine

PharmaGrade, Ajinomoto, EP, JP, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture

Synonym: (S)-2-Amino-4-methylpentanoic acid

  • CAS Number 61-90-5

  • Linear Formula (CH3)2CHCH2CH(NH2)CO2H

  • Molecular Weight 131.17

  •  Beilstein/REAXYS Number 1721722

  •  EC Number 200-522-0

  •  MDL number MFCD00002617

  •  eCl@ss 32160406

  •  PubChem Substance ID 57654329

  •  NACRES NA.26

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Properties

Related Categories Amino Acids, Amino acids, Analytical/Chromatography, Biochemicals and Reagents, Cell Biology,
biological source   non-animal source
Agency/Method   EP
  JP
  USP
product line   PharmaGrade
assay   ≥98.5%
form   crystalline powder
mfr. no.   Ajinomoto
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, heavy metals, residual solvents, tested
mp   >300 °C (lit.)
solubility   1 M HCl: 50 mg/mL
Featured Industry   Pharmaceutical (small molecule)
foreign activity   cytotoxicity, tested
SMILES string   CC(C)C[C@H](N)C(O)=O
InChI   1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChI key   ROHFNLRQFUQHCH-YFKPBYRVSA-N

Description

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.
To request the Enhanced Quality Product Documentation for this product, please contact Customer Support and select ‘Product Documentation’. Please note that access to the Enhanced Quality Product Documentation for this product requires a confidentiality disclosure agreement.

Application

L-Leucine is an essential amino acid. It is also considered to be a branched chain amino acid, along with L-Isoleucine and L-Valine. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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