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  • L7035 - clasto-Lactacystin β-lactone

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L7035 Sigma-Aldrich

clasto-Lactacystin β-lactone

  • CAS Number 154226-60-5

  • Empirical Formula (Hill Notation) C10H15NO4

  • Molecular Weight 213.23

  •  MDL number MFCD01076526

  •  PubChem Substance ID 24896450

  •  NACRES NA.77

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Properties

Related Categories Application Index, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, CI-CZ,
Quality Level   100
assay   ≥95% (HPLC)
form   film
solubility   DMSO: soluble 25 mg/mL
storage temp.   −20°C
SMILES string   [H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
InChI   1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
InChI key   FWPWHHUJACGNMZ-NBBQQVJHSA-N

Description

Application

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

Biochem/physiol Actions

Cell-permeable and irreversible proteasome inhibitor. Lactacystin acts as a precursor for clasto-lactacystin β-lactone.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Peer-Reviewed Papers
15

References

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