EMAIL THIS PAGE TO A FRIEND
L8000 Sigma-Aldrich

L-Leucine

reagent grade, ≥98% (HPLC)

Synonym: (S)-2-Amino-4-methylpentanoic acid

  • CAS Number 61-90-5

  • Linear Formula (CH3)2CHCH2CH(NH2)CO2H

  • Molecular Weight 131.17

  •  Beilstein Registry Number 1721722

  •  EC Number 200-522-0

  •  MDL number MFCD00002617

  •  eCl@ss 32160406

  •  PubChem Substance ID 24896488

Purchase

Description

Packaging

1 kg in poly bottle

25, 50, 100, 250 g in poly bottle

Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles

Related Content

Amino Acids Reference Chart

The hydrophobicity index is a measure of the relative hydrophobicity, or how soluble an amino acid is in water. In a protein, hydrophobic amino acids are likely to be found in the interior, whereas h...
Keywords: Gene expression, Mass spectrometry

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?