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M0252 Sigma-Aldrich

Methylglyoxal solution

~40% in H2O

Synonym: Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde

  • CAS Number 78-98-8

  • Linear Formula CH3COCHO

  • Molecular Weight 72.06

  •  Beilstein/REAXYS Number 906750

  •  MDL number MFCD00006960

  •  PubChem Substance ID 24896540

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Properties

Related Categories Aldehydes, Building Blocks, C1 to C6, Carbonyl Compounds, Cell Biology,
InChI Key   AIJULSRZWUXGPQ-UHFFFAOYSA-N
concentration   ~40% in H2O
density   1.17 g/mL at 25 °C (lit.)
storage temp.   2-8°C

Description

General description

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.

Application

Methylglyoxal solution has been used:
• to assess glyoxalase 1 (GLO1) enzymatic activity
• as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro
• to regulate anxiety like behavior in mice
• to induce peritoneal fibrosis in rats
• to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts
• for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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