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  • M0639 - 6α-Methylprednisolone

M0639 Sigma-Aldrich



Synonym: 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Medrol, Medrone

  • CAS Number 83-43-2

  • Empirical Formula (Hill Notation) C22H30O5

  • Molecular Weight 374.47

  •  Beilstein/REAXYS Number 2340300

  •  EC Number 201-476-4

  •  MDL number MFCD00010591

  •  PubChem Substance ID 24896564

  •  NACRES NA.77



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
biological source   synthetic
assay   ≥98%
form   powder
application(s)   cell analysis: suitable
solubility   chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
shipped in   ambient
storage temp.   room temp
SMILES string   [H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI   1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
Gene Information   human ... NR3C1(2908)
rat ... Nr3c1(24413)



6α-Methylprednisolone has been used:
• to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
• to induce depletion of CD14+ CD16+ monocytes
• to study its effect on behavioral and sensory afferent hypersensitivity

Biochem/physiol Actions

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.


Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

GHS08  GHS08
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What solvents can be used forMethylprednisolone?
Sigma tests the solublity of Methylprednisolone at 50 mg/ml in chloroform:methanol (1:1) yielding a clear, colorless to faint yellow solution.This product is practically insoluble in water, soluble 1 in 100 of dehydrated ethanol (10 mg/ml), slightly soluble in chloroform and ether; sparingly soluble in dioxan and methanol. It has been reported that this product is soluble in DMSO at a concentration of 100 mM. An NMR has been run using DMSO-d6 suggesting this product is soluble at 5-10 mg/ml in DMSO.
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