• USA Home
  • M0880 - Ethyl methanesulfonate

EMAIL THIS PAGE TO A FRIEND
M0880 Sigma-Aldrich

Ethyl methanesulfonate

liquid

Synonym: Ethyl mesylate, Methanesulfonic acid ethyl ester

  • CAS Number 62-50-0

  • Linear Formula CH3SO3CH2CH3

  • Molecular Weight 124.16

  •  Beilstein/REAXYS Number 773969

  •  EC Number 200-536-7

  •  MDL number MFCD00007559

  •  PubChem Substance ID 24896575

  •  NACRES NA.25

Purchase

Properties

InChI Key   PLUBXMRUUVWRLT-UHFFFAOYSA-N
form   liquid
refractive index   n20/D 1.418 (lit.)
bp   85-86 °C/10 mmHg (lit.)
density   1.206 g/mL at 20 °C

Description

Application

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Packaging

1, 5, 10, 25, 100 g in glass bottle

Biochem/physiol Actions

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
3
RTECS 
PB2100000
Flash Point(F) 
212 °F
Flash Point(C) 
100 °C

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
I have heard that I need to use sodium thiosulfate with Product M0880, Ethyl methanesulfonate (EMS), but Im not sure how. Can you tell me?
EMS is a mutagen. After treating cells with EMS, the mutagenesis reaction may be stopped by adding the appropriate volume of a 5% sodium thiosulfate solution.The use of a 10% sodium thiosulfate solution with 1% TWEEN 20 has been used to clean surfaces and items such as pipettes that have been contaminated with EMS in mineral oil.
Is Product M0880, Ethyl methanesulfonate (EMS), sterile?
It is not necessarily sterile. For those applications that require a sterile EMS solution, the EMS should be added to the appropriate buffer or medium. The buffer or medium should then be sterile-filtered.
I received a liquid. What is Product M0880, Ethyl methanesulfonate (EMS), dissolved in?
Its actually not dissolved in anything. Pure EMS is itself a liquid at room temperature; that is, the melting point is below room temperature.
How does Product M0880, Ethyl methanesulfonate (EMS), compare toProduct 64292, which is the same chemical?
Product No. 64292 is tested for purity by a titration assay. Although M0880 is likely to be of similar quality, there is no purity assay performed on it.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
Show more questions
Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)
Keywords: Chromatography, Gas chromatography, Mass selective detector, Purification

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on SLB®-5ms (30 m x 0.25 mm I.D., 0.50 μm)

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on SLB®-5ms (30 m x 0.25 mm I.D., 0.50 μm)
Keywords: Chromatography, Gas chromatography, Purification

Related Content

Carcinogen Selector - Reproductive System - Lung

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs acro...
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Respiratory System

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs acro...
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Urinary System - Kidney

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs acro...
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Urinary System

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs acro...
Keywords: Cancer, Carcinogens, Respiratory

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?