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M1787 Sigma-Aldrich

Manganese(II) chloride solution

for molecular biology, BioReagent, storage temp.: room temp



Related Categories Automated Sequencing, Biochemicals, Gel Solutions and Reagents, Molecular Biology, Molecular Biology Reagents More...
Quality Level   200
grade   for molecular biology
sterility   0.2 μm filtered
product line   BioReagent
form   liquid
concentration   1.00 M±0.01 M
cation traces   heavy metals (as Pb): ≤5 ppm
foreign activity   DNase, Exonuclease; NICKase, Endonuclease; and protease, none detected
storage temp.   room temp
SMILES string   Cl[Mn]Cl
InChI   1S/2ClH.Mn/h2*1H;/q;;+2/p-2


General description

Manganese (II) chloride (MnCl2) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism. MnCl2 has been used in reverse transcription reaction mix to enhance the template-switching efficiency.

MnCl2 solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn2+ can be substituted for Mg2+ as a divalent metal ion to facilitate DNase I activity in presence of Ca2+.


Manganese (II) chloride solution has been used:
• in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicity
• in high ionic strength reaction mixture to determine RNA polymerase I and II activity
• in reverse transcription reaction mix as a source of Mn2+ ions

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Protocols & Articles


Manganese (II) chloride solution for molecular biology

This product is a 1.00 ± 0.01 M solution, prepared in 18 megohm water, and is 0.2 µm filtered. It is designated as Molecular Biology grade and is suitable for molecular biology applications. This pro...
Keywords: Biochemistry, Gene expression, Molecular biology, Purification

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