EMAIL THIS PAGE TO A FRIEND
M2696 Sigma-Aldrich

Metyrapone

≥98% (HPLC), solid

Synonym: 2-Methyl-1,2-di-3-pyridyl-1-propanone, Metyrapone, Su-4885

  • CAS Number 54-36-4

  • Empirical Formula (Hill Notation) C14H14N2O

  • Molecular Weight 226.27

  •  Beilstein/REAXYS Number 163023

  •  EC Number 200-206-2

  •  MDL number MFCD00006397

  •  PubChem Substance ID 329817949

  •  NACRES NA.77

Purchase

Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
application(s)   toxicology assay: suitable
mp   52-55 °C (lit.)
solubility   H2O: <2 mg/mL
  DMSO: >20 mg/mL
originator   Novartis
shipped in   ambient
storage temp.   room temp
SMILES string   CC(C)(c1cccnc1)C(=O)c2cccnc2
InChI   1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
InChI key   FJLBFSROUSIWMA-UHFFFAOYSA-N

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
UC3050000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?