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M2696 Sigma-Aldrich

Metyrapone

≥98% (HPLC), solid

Synonym: 2-Methyl-1,2-di-3-pyridyl-1-propanone, Metyrapone, Su-4885

  • CAS Number 54-36-4

  • Empirical Formula (Hill Notation) C14H14N2O

  • Molecular Weight 226.27

  •  Beilstein Registry Number 163023

  •  EC Number 200-206-2

  •  MDL number MFCD00006397

  •  PubChem Substance ID 329817949

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   FJLBFSROUSIWMA-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
mp   52-55 °C (lit.)
solubility   H2O: <2 mg/mL
  DMSO: >20 mg/mL
originator   Novartis
storage temp.   room temp

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UC3050000
Flash Point(F) 
>230 °F
Flash Point(C) 
>110 °C

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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