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M2892 Sigma-Aldrich

Methylphenidate hydrochloride

Synonym: threo-Methyl α-phenyl-α-(2-piperidyl)acetate hydrochloride, Ritalin hydrochloride

  • CAS Number 298-59-9

  • Empirical Formula (Hill Notation) C14H19NO2 · HCl

  • Molecular Weight 269.77

  •  EC Number 206-065-3

  •  MDL number MFCD00058191

  •  PubChem Substance ID 24896775

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
drug control   USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)
Featured Industry   Forensics and Toxicology
originator   Johnson & Johnson
storage temp.   room temp
SMILES string   Cl[H].COC(=O)C(C1CCCCN1)c2ccccc2
InChI   1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H
InChI key   JUMYIBMBTDDLNG-UHFFFAOYSA-N
Gene Information   human ... SLC6A2(6530), SLC6A3(6531)

Description

Biochem/physiol Actions

CNS stimulant; releases catecholamines; potent inhibitor of dopamine reuptake

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
TM3850000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

GC Analysis of Methylphenidate (Ritalin) Enantiomers (N-Trifluoroacetyl Derivatives) on Astec® CHIRALDEX® B-DA

From our library of Articles, Sigma-Aldrich presents GC Analysis of Methylphenidate (Ritalin) Enantiomers (N-Trifluoroacetyl Derivatives) on Astec® CHIRALDEX® B-DA
Keywords: Chromatography, Clinical, Flame ionization detector, Forensic, Gas chromatography, Pharmaceutical, Purification

HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec® CHIROBIOTIC® T2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec® CHIROBIOTIC® T2
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec® CHIROBIOTIC® V2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methylphenidate (Ritalin) Enantiomers on Astec® CHIROBIOTIC® V2
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Methylphenidate Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methylphenidate Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Ritalinic Acid and Ritalin (Methylphenidate) Enantiomers on Astec® CHIROBIOTIC® V2 with T2 Guard Column

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ritalinic Acid and Ritalin (Methylphenidate) Enantiomers on Astec® CHIROBIOTIC® V2 with T2 Guard Column
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

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Peer-Reviewed Papers
15

References

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