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M3074 Sigma-Aldrich

MMPIP

≥98% (HPLC)

Synonym: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one

  • CAS Number 479077-02-6

  • Empirical Formula (Hill Notation) C19H15N3O3

  • Molecular Weight 333.34

  •  MDL number MFCD12195836

  •  PubChem Substance ID 329817961

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to off-white
solubility   DMSO: ≥10 mg/mL
originator   Merck & Co., Inc., Kenilworth, NJ, U.S.
storage temp.   room temp
SMILES string   COc1ccc(cc1)C2=Cc3onc(-c4ccncc4)c3C(=O)N2C
InChI   1S/C19H15N3O3/c1-22-15(12-3-5-14(24-2)6-4-12)11-16-17(19(22)23)18(21-25-16)13-7-9-20-10-8-13/h3-11H,1-2H3
InChI key   PDWYBOZNEVALOV-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MMPIP is a potent, selective, allosteric antagonist of metabotropic glutamate receptor 7 (mGluR7). It also displays intrinsic activity and acts as an inverse agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Glutamate Receptors (G Protein Family)

The existence of G protein-coupled glutamate receptors (also called "€œmetabotropic" glutamate or mGlu's), belonging to the seven transmembrane spanning superfamily of receptors, was shown definitive...
Keywords: Atomic absorption spectroscopy, Cloning, Gene expression, Ligands, Neurotransmission, Neurotransmitters, Obesity, Parkinson Disease, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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