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M3281 Sigma-Aldrich

α-Methyl-DL-tyrosine methyl ester hydrochloride

≥98% (HPLC)

Synonym: α-MT methyl ester hydrochloride, 2-Methyl-4-hydroxy-DL-phenylalanine methyl ester hydrochloride, AMPT methyl ester hydrochloride

  • CAS Number 7361-31-1

  • Linear Formula 4-(HO)C6H4CH2C(CH3)(NH2)CO2CH3 · HCl

  • Molecular Weight 245.70

  •  Beilstein/REAXYS Number 5163031

  •  EC Number 230-900-0

  •  MDL number MFCD00012606

  •  PubChem Substance ID 24278548

  •  NACRES NA.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Neuroscience, Neurotransmission,
assay   ≥98% (HPLC)
mp   192 °C (dec.) (lit.)
solubility   DMSO: ≥20 mg/mL, clear, colorless to faintly yellow
storage temp.   −20°C
SMILES string   Cl[H].COC(=O)C(C)(N)Cc1ccc(O)cc1
InChI   1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H
InChI key   OOVDEPZODSXAMU-UHFFFAOYSA-N
Gene Information   human ... TH(7054)

Description

Application

α-Methyl-DL-tyrosine methyl ester hydrochloride has been used to evaluate norepinephrine turnover.

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

α-Methyl-DL-tyrosine (α-MT) prevents hyperactivity, sniffing-licking-gnawing syndrome, anorexia and ameliorates certain effects of amphetamine. It inhibits dopamine production and prevents apoptosis stimulated by mutant α-synuclein.

Tyrosine hydroxylase inhibitor.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
YP2900000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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