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M3449 Sigma-Aldrich

Mephedrone hydrochloride

Synonym: 4-Methylmethcathinone hydrochloride

  • CAS Number 1189726-22-4

  • Empirical Formula (Hill Notation) C11H15NO·HCl

  • Molecular Weight 213.70

  •  MDL number MFCD14585021

  •  PubChem Substance ID 329817974

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, M,
InChI Key   DLQZFTUKJGRPLZ-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
drug control   USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)
color   white to off-white
solubility   DMSO: >20 mg/mL
storage temp.   room temp

Description

Biochem/physiol Actions

Mephedrone is an inhibitor of monoamine transporter present in the brain and periphery. Mephedrone bears a chiral center and can be found in two enantiomers R-mephedrone and S-mephedrone. Its racemic form is often used as a drug. Mephedrone in rats is known to cause high blood pressure and heart rate, as well as stimulates locomotor hyperactivity. Human trail reveal that mephedrone has the ability to induce euphoria and pleasure.

Mephedrone is a synthetic stimulant, an analog of Cathinone and Methamphetamine.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Dopamine Receptors

Dopamine receptors were initially differentiated into two major types based on the ability of dopamine to stimulate (D1) or inhibit (D2) adenylyl cyclase activity and produce the second-messenger mol...
Keywords: Atomic absorption spectroscopy, Dopamine agents, Gene expression, Genetic, Genetics, Ligands, Methylations, Parkinson Disease, Schizophrenia, Transduction

GC Analysis of Volatiles in Green Arabica Coffee on SUPELCOWAX® 10 after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles in Green Arabica Coffee on SUPELCOWAX® 10 after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber
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LC/MS (TOF) Analysis of Illicit Bath Salts in Urine on Ascentis® Express HILIC after Solid Phase Extraction (SPE) using Supel™-Select SCX

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Illicit Bath Salts in Urine on Ascentis® Express HILIC after Solid Phase Extraction (SPE) using Supel™-Select SCX
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Phase transitions, Solid phase extractions

LC/MS (TOF) Analysis of Illicit Bath Salts on Ascentis® Express HILIC

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LC/MS Analysis of Illicit Bath Salts on Ascentis® Express HILIC, Fast Analysis

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Illicit Bath Salts on Ascentis® Express HILIC, Fast Analysis
Keywords: Chromatography, Enzyme-linked immunosorbent assay, Forensic, High performance liquid chromatography, Mass spectrometry, Separation

LC/MS Analysis of Illicit Bath Salts on Ascentis® Express HILIC, Set 4

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Illicit Bath Salts on Ascentis® Express HILIC, Set 4
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Solvents

LC/MS Analysis of Illicit Phenethylamine and Cathinone"Bath Salts" in Plasma on Ascentis® Express HILIC after Extraction using SPME LC Tips

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Illicit Phenethylamine and Cathinone"Bath Salts" in Plasma on Ascentis® Express HILIC after Extraction using SPME LC Tips
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solid phase microextractions, Solvents

LC/MS Analysis of Isobaric Bath Salts Mephedrone, Buphedrone, N-Ethylcathinone and MDAI on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Isobaric Bath Salts Mephedrone, Buphedrone, N-Ethylcathinone and MDAI on Ascentis® Express HILIC
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Peer-Reviewed Papers
15

References

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