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M4135 Sigma

α-Melanocyte stimulating hormone

≥97% (HPLC)

Synonym: α-MSH, α-Melanotropin



Amino Acid Sequence


Antibody Adsorbant


Biochem/physiol Actions

Pituitary hormone which causes darkening skin pigmentation from amphibians to humans. In mammals, it can also have behavioral effects on learning, attention, and memory.

Hormone that stimulates melanogenesis; facilitates learning and memory; affects inflammatory and immune responses and peripheral nerve regeneration.

α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock. α-MSH has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.


Derived from ACTH 1-13

Other Notes

Lyophilized from 0.1% TFA in H2O


1, 5 mg in glass bottle


α-Melanocyte stimulating hormone (α–MSH) has been used for following studies:
•  it has been Intracerebroventricularly (icv) injected to mice for behavioral studies.
•  to determine the effect of α−MSH on growth of stationary Nb 2 node lymphoma cell cultures.
•  to determine the effect of α−MSH on leptin secretion in the primary cultures of differentiated adipocytes.
•  α−MSH promoted melanin production in the B16-F1 cells from murine melanoma cell line.

General description

α-Melanocyte-stimulating hormone (α-MSH) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation. Pro-inflammatory cytokines or UV light induced epidermal cells such as keratinocytes and melanocytes synthesize and discharge α–MSH. Poopiomelanocortin (POMC) acts as a precursor for α-Melanocyte-stimulating hormone (α-MSH) production.

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Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers


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