M4667 Sigma-Aldrich


~97% (titration)

Synonym: (±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone

  • CAS Number 674-26-0

  • Empirical Formula (Hill Notation) C6H10O3

  • Molecular Weight 130.14

  •  Beilstein/REAXYS Number 80960

  •  EC Number 211-615-0

  •  MDL number MFCD00006648

  •  PubChem Substance ID 24896934

  •  NACRES NA.25



Related Categories Allium cepa (Onion), Cell Biology, Lipid, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart,
Quality Level   200
assay   ~97% (titration)
storage temp.   −20°C
SMILES string   CC1(O)CCOC(=O)C1
InChI   1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3


General description

Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation.


(±)-Mevalonolactone is used to:
• study the effect of statin on the prenylation of Ras and Rho GTPases
• analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes
• study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)


1, 5, 10 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M4667.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

May also be liquid!

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
235.4 °F - closed cup
Flash Point(C) 
113 °C - closed cup


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Why did M4667, (±)-Mevalonolactone, arrive as a liquid?
As noted onthe Sigma Aldrichwebpagefor product M4667, (±)-Mevalonolactone, this product "may also be a liquid." The melting point for this chemical is 26-28°C, which is approximately room temperature. Because of this, the product may arrive as a liquid, but if stored at -20°C it should return to a solid/semi-solid state. This product does not arrive in solution and will not have a concentration value.
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Protocols & Articles


Cholesterol Biosynthesis

Cholesterol levels in the body come from two sources, dietary intake and biosynthesis. The majority of cholesterol utilized by healthy adults is synthesized in the liver, which produces ~70% of the t...
BioFiles 2007, 2.7, 3.
Keywords: Catalysis, Decarboxylations, Metabolic Pathways, Oxidations, PAGE, Phosphorylations, Reductions

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

OAMLS Online Plate Map

OAMLS compounds are conveniently provided at 5µg per well, enough for multiple injections. These are high purity (>95%) compounds supplied in an economical, ready to use format. Compounds are arrange...
Keywords: Metabolites

Peer-Reviewed Papers


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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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