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M5273 Sigma-Aldrich

Monensin sodium salt

90-95% (TLC)

Synonym: Monensin A sodium salt

  • CAS Number 22373-78-0

  • Empirical Formula (Hill Notation) C36H61NaO11

  • Molecular Weight 692.85

  •  Beilstein/REAXYS Number 4122200

  •  EC Number 244-941-7

  •  MDL number MFCD00077826

  •  PubChem Substance ID 24896992

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Description

General description

Chemical structure: polyether

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis in poultry production.

Application

Monensin sodium salt has been used:
• for the intracellular staining of cytokines
• to study its effects on the regulation of nuclear factor-κ B (NF-κB ) activation
• as a positive control to study its effects on in vitro rumen fermentation

Packaging

1, 5 g in poly bottle

500 mg in poly bottle

Biochem/physiol Actions

Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGII
WGK Germany 
3
RTECS 
JH2830000

Documents

Certificate of Analysis

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Certificate of Origin

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

HPLC Analysis of Veterinary Antibiotics on Discovery® HS C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Veterinary Antibiotics on Discovery® HS C18
Keywords: Antibiotics, Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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