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M5324 Sigma-Aldrich

PX 12

≥98% (HPLC), powder

Synonym: 2-[(1-methylpropyl)dithio]-1H-imidazole

  • CAS Number 141400-58-0

  • Empirical Formula (Hill Notation) C7H12N2S2

  • Molecular Weight 188.31

  •  MDL number MFCD18086851

  •  PubChem Substance ID 329818011

  •  NACRES NA.77

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Properties

Related Categories Aerobic Glycolysis (the Warburg Effect), Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Metabolism, Cancer Research,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   off-white to tan
solubility   DMSO: >25 mg/mL
storage temp.   2-8°C
SMILES string   CCC(C)SSc1ncc[nH]1
InChI   1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
InChI key   BPBPYQWMFCTCNG-UHFFFAOYSA-N

Description

Application

PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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