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  • M5435 - 6-Methyl-2-(phenylethynyl)pyridine hydrochloride

M5435 Sigma

6-Methyl-2-(phenylethynyl)pyridine hydrochloride

≥98% (HPLC)

Synonym: MPEP hydrochloride

  • CAS Number 219911-35-0

  • Empirical Formula (Hill Notation) C14H11N · HCl

  • Molecular Weight 229.70

  •  MDL number MFCD02262119

  •  PubChem Substance ID 24278557



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   off-white to light tan
solubility   DMSO: 10 mg/mL, clear
storage temp.   room temp
Gene Information   human ... GRIN2B(2904), GRM5(2915)
rat ... Grm5(24418)


Biochem/physiol Actions

Highly selective, non-competitive mGluR5 metabotropic glutamate receptor antagonist.


5, 25 mg in glass bottle

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety Information

NONH for all modes of transport
Protocols & Articles


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