• USA Home
  • M6067 - Monoclonal Anti-MRP5 antibody produced in rat

EMAIL THIS PAGE TO A FRIEND
Purchase

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Multi-Drug Resistance, Antibodies to Drug Efflux Pumps,
conjugate   unconjugated
clone   M5I-1, monoclonal
biological source   rat
application(s)   immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations
  immunohistochemistry (frozen sections): 1:20 using acetone-fixed frozen sections
  western blot: 1:20-1:50
species reactivity   human
mol wt   antigen 190-200 kDa
shipped in   dry ice
storage temp.   −20°C
antibody form   tissue culture supernatant
isotype   IgG2a
Quality Level   200
antibody product type   primary antibodies
concentration   250 μg/mL
UniProt accession no.   O15440
Gene Information   human ... ABCC5(10057)

Description

General description

Multidrug resistance associated protein 5 (MRP5) is a short type organic anion pump which belongs to the ATP-binding cassette transporter superfamily.

Specificity

Reacts with an internal epitope of MRP5. Does not cross-react with the human MDR1, MRP1, MRP2, MRP3 gene products.

Immunogen

human MRP5 (amino acids 82-168) bacterial fusion protein.

Physical form

Supplied in serum-free culture medium containing 0.7% bovine serum albulin and 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Multidrug resistance associated protein 5 (MRP5) is involved in pumping out cyclic guanosine monophosphate (cGMP) from the cell. It can also export anti-viral and anti-cancer drugs. MRP5 has been shown to be overexpressed in breast cancer.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles

Articles

ABC Transporters and Cancer Drug Resistance

Chemotherapy is the treatment of choice against many types of cancer. However, over time chemotherapeutic drugs can become less effective due to the development of resistance that involves a group of...
BioFiles 2007, 2.4, 7.
Keywords: Absorption, Cancer, Clinical, Cloning, Combinatorial synthesis, Diseases, Enzymology, Gene expression, Genetic, Immunology, Pharmaceutical, Reductions, Transfection

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

Related Content

Antibody Explorer | Buy Primary Antibodies & Secondary Antibodies

Primary, Secondary and Recombinant Monoclonal Antibodies Providing highly cited primary and secondary antibodies, we have you covered for your ELISA, western blot, immunohistochemistry or other assay...
Keywords: Alzheimer Disease, Cancer, Chromatin immunoprecipitation, Diagnostic, Enzyme-linked immunosorbent assay, Flow cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Neuroscience, Western blot

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?