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  • M6442 - Monoclonal Anti-MRP5 antibody produced in rat

M6442 Sigma-Aldrich

Monoclonal Anti-MRP5 antibody produced in rat

250 μg/mL, clone M5II-54, tissue culture supernatant

Synonym: Anti-Multidrug Resistance Associated Protein 5



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Multi-Drug Resistance, Antibodies to Drug Efflux Pumps,
conjugate   unconjugated
clone   M5II-54, monoclonal
biological source   rat
application(s)   immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations
  immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections
  western blot: 1:20-1:50
species reactivity   human
mol wt   antigen 199-200 kDa
shipped in   dry ice
storage temp.   −20°C
antibody form   tissue culture supernatant
isotype   IgG2a
Quality Level   200
antibody product type   primary antibodies
concentration   250 μg/mL
UniProt accession no.   O15440
Gene Information   human ... ABCC5(10057)


General description

Multidrug resistance associated protein 5 (MRP5) is a short type organic anion pump which belongs to the ATP-binding cassette transporter superfamily.


Reacts with an internal epitope of MRP5. Does not cross-react with the human MDR1, MRP1, MRP2, MRP3 gene products.


human MRP5 (amino acids 722-911) bacterial fusion protein.

Physical form

Supplied in serum-free culture medium containing 0.7% bovine serum albulin and 0.1% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Multidrug resistance associated protein 5 (MRP5) is involved in pumping out cyclic guanosine monophosphate (cGMP) from the cell. It can also export anti-viral and anti-cancer drugs. MRP5 has been shown to be overexpressed in breast cancer.

Safety & Documentation

Safety Information

WGK Germany 
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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