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M6638 Sigma

[Met5]Enkephalin acetate salt hydrate

≥95.0% (HPLC), powder

Synonym: Enkephalin M, [5-Methionine]Enkephalin

  • CAS Number 82362-17-2

  • Empirical Formula (Hill Notation) C27H35N5O7S · xC2H4O2 · yH2O

  • Molecular Weight 573.66 (anhydrous free base basis)

  •  Beilstein Registry Number 3042295

  •  MDL number MFCD03788202

  •  PubChem Substance ID 24897102

  • Popular Documents:  Specification Sheet (PDF)  



Related Categories Cell Biology, Cell Signaling and Neuroscience, Enkephalins, Neuropeptides, Opioid Peptides,
assay   ≥95.0% (HPLC)
form   powder
composition   acetate, 2.5-20%
color   white
storage temp.   −20°C
Gene Information   human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)


Amino Acid Sequence



[Met5] Enkephalin acetate salt hydrate has been used to study the effect of mutations in opioid growth factor receptor on growth of human cancer cell line.

Biochem/physiol Actions

Met-enkephalin is endogenous opioid neurotransmitter/neuromodulator with agonist activity at μ and δ opioid receptors. Enhancement of immune system function is mediated through met-enkephalin receptors on leukocytes. Met-enkephalin also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors.

Opioid peptides play a crucial role in various physiological process such as pain mediation, opiate dependence and euphoria and members of this class contain aromatic residues in positions 1 and 4. [Met5] Enkephalin acts as a cytokine and is implicated in improving immune response in patients with cancer or AIDS. [Met5] Enkephalin boosts immune functions at low concentration and suppress at high concentration. ME is associated with glucose homeostasis. Increased concentration of ME is observed in plasma of type I diabetic patients.

General description

[Met5] Enkephalin (ME) is an opioid pentapeptide, which acts as a neurotransmitter or neuromodulator in the central nervous system. [Met5] Enkephalin is activated on interaction with three main subtypes of receptors including μand δ opioid receptors mediating classic opioid effects of met-Enk and ζ -receptors mediating non-opioid actions of the peptide, i.e. retardation of cell growth. [Met5] Enkephalin is derived from precursor peptide pro-methionine-enkephalin in vitro consisting of H-Tyr-Gly-Gly-Phe-Met-Arg-OH amino acid sequence. The peptide activity is observed in the central nervous, neuroendocrine and immune systems.

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Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers


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