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M6690 Sigma-Aldrich

MDL 28170

≥90% (TLC)

Synonym: Calpain Inhibitor III

  • CAS Number 88191-84-8

  • Empirical Formula (Hill Notation) C22H26N2O4

  • Molecular Weight 382.45

  •  MDL number MFCD00798796

  •  PubChem Substance ID 24278565

  •  NACRES NA.77

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Properties

Related Categories Aldehydes, Apoptosis Inhibitors, Apoptosis and Cell Cycle, Application Index, Bioactive Small Molecule Alphabetical Index,
Quality Level   200
assay   ≥90% (TLC)
composition   Peptide Content, >90%
solubility   DMSO: 26 mg/mL
  H2O: insoluble
  methanol: soluble
shipped in   wet ice
storage temp.   2-8°C
SMILES string   [H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C
InChI   1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1
InChI key   NGBKFLTYGSREKK-ANYOKISRSA-N
Gene Information   human ... CAPN1(823), CAPN2(824)

Description

Amino Acid Sequence

Z-Val-Phe-al

Biochem/physiol Actions

MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during t...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Cell division, Cell proliferation, DNA replication, Diseases, Genetic

Peer-Reviewed Papers
15

References

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