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M6760 Sigma-Aldrich

Myricetin

≥96.0%, crystalline

Synonym: 3,3′,4′,5,5′,7-Hexahydroxyflavone, Cannabiscetin, Myricetol

  • CAS Number 529-44-2

  • Empirical Formula (Hill Notation) C15H10O8

  • Molecular Weight 318.24

  •  Beilstein/REAXYS Number 332331

  •  EC Number 208-463-2

  •  MDL number MFCD00006827

  •  PubChem Substance ID 24278566

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Description

Application

Myricetin has been used:
• to investigate its effect on end product (AGE)- bovine serum albumin mediated phosphorylation of mitogen-activated protein kinase(ERK1)
• as a standard for the quantification of phenolics from noni plant extracts using high performance liquid chromatography(HPLC)
• as a standard for characterization of phenolic compounds from Hibiscus sabdariffa using ultra-high performance liquid chromatography(UHPLC)

Biochem/physiol Actions

Myricetin is a naturally occurring flavonol with antioxidant property. It displays moderate membrane permeability and it degrades rapidly at elevated pH. Myricetin is one of the major flavonoid present in edible plants and has anticarcinogenic and antimutagenic functionality. It comprises of two benzene rings A and B. Ring B intercalates with nucleotide staking and inhibits bacterial DNA synthesis. Myricetin elicits protective function against oxidative stress generated by tert-butylhydroperoxide (t-BHP) in diabetic rat and improves glutathione peroxidase (GPx) and xanthine oxidase (XO) enzyme activity. It also lowers the glycation of low-density lipoprotein.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6760.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

HPLC Analysis of Flavones on Discovery® HS PEG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flavones on Discovery® HS PEG
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Flavonoids on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flavonoids on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Vitamins

Peer-Reviewed Papers
15

References

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