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  • M6792 - Anti-Macrophage Inflammatory Protein-1β antibody produced in goat

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M6792 Sigma-Aldrich

Anti-Macrophage Inflammatory Protein-1β antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-MIP-1β

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Description

General description

The antibody will neutralize the biological activity of recombinant human, but not mouse MIP-1β. It will not neutralize the biological activity of recombinant human or mouse MIP-1α.

Immunogen

recombinant human MIP-1β, expressed in Sf 21 insect cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Packaging

1 mg in glass bottle

Biochem/physiol Actions

Macrophage inflammatory protein-1β (CCL4) belongs to a family of MIP-1 chemotactic cytokines (CC). The members of MIP-1 family have the ability to self-associate and form aggregates of high molecular weight. The self- aggregation is a reversible process and occurs in T cells, B cells and macrophages in response to inflammatory factors and bacterial endotoxins. This response results in inflammation and platelet degranulation.

Preparation Note

Purified using protein G.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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