• USA Home
  • M6908 - Myeloperoxidase from human leukocytes

M6908 Sigma-Aldrich

Myeloperoxidase from human leukocytes

lyophilized powder, ≥50 units/mg protein

Synonym: MPO, Peroxidase, myelo



General description

Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.


Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.

Biochem/physiol Actions

Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).

Other Notes

Lysosomal heme-containing protein.

Unit Definition

One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C

Physical form

Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride

Analysis Note

Source material tested and found negative for antibody to HIV and for HBSAG.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Certificate of Origin

Protocols & Articles

Related Content

Enzymes & Proteins

Application Index | Enzyme Index | Substrate Index | Inhibitor Index | Cofactor Index | Lectin Index
Keywords: Cell signaling, Diagnostic, Drug discovery, Metabolomics, Molecular biology

Peer-Reviewed Papers


Related Products


Product #


Add to Cart

S2002 Sodium azide, ReagentPlus®, ≥99.5%

related product

Product #


Add to Cart

92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C


Product #


Add to Cart

D9143 o-Dianisidine, peroxidase substrate
A0156 N-(4-Aminobutyl)-N-ethylisoluminol, ≥90%
A4685 Luminol sodium salt
A1888 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, ≥98% (HPLC)
G5502 Guaiacol, oxidation indicator
A3537 5-Aminosalicylic acid, ≥99%
A4382 4-Aminoantipyrine, reagent grade
A8264 4-Aminophthalhydrazide
A5754 3-Amino-9-ethylcarbazole, ≥95% (HPLC), powder
A8511 Luminol, ≥97% (HPLC)

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?