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M7033 Sigma-Aldrich

NG-Methyl-L-arginine acetate salt

≥98% (TLC)

Synonym: Nω-Methyl-L-arginine acetate salt, L-NMMA, N5-(Methylamidino)-L-ornithine acetate salt, NG-Monomethyl-L-arginine acetate salt

  • CAS Number 53308-83-1

  • Empirical Formula (Hill Notation) C7H16N4O2 · C2H4O2

  • Molecular Weight 248.28

  •  Beilstein/REAXYS Number 6674255

  •  MDL number MFCD00069311

  •  PubChem Substance ID 24278043

  •  NACRES NA.77




NG-Methyl-L-arginine acetate salt has been used:
• as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice
• as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells
• as an inhibitor to monitor NO levels in hemocytes respiratory burst assay


5, 25 mg in glass bottle

Biochem/physiol Actions

NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

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Peer-Reviewed Papers


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