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M7067 Sigma-Aldrich

Monoclonal Anti-Major Vault Protein antibody produced in mouse

250 μg/mL, clone LRP-56, tissue culture supernatant

Synonym: Anti-LRP, Anti-Lung Resistance Protein, Anti-MVP

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Multi-Drug Resistance, Antibodies to Other MDR-related Proteins,
conjugate   unconjugated
clone   LRP-56, monoclonal
biological source   mouse
application(s)   flow cytometry: suitable
  immunocytochemistry: 1:20 using air-dried or acetone-fixed cells
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:20
  immunohistochemistry (frozen sections): 1:20
species reactivity   human
mol wt   antigen ~110 kDa
shipped in   dry ice
storage temp.   −20°C
antibody form   tissue culture supernatant
antibody product type   primary antibodies
Quality Level   200
concentration   250 μg/mL
UniProt accession no.   Q14764
Gene Information   human ... MVP(9961)

Description

General description

Major vault protein (MVP) is also called lung resistance protein (LRP). It forms the outer shell of vaults (ribonucleoprotein particles present in the cytoplasm).

Specificity

Reacts with an internal epitope of LRP/MVP (P110).

Immunogen

drug resistant tumor cell line SW-1573/2R120.

Physical form

Supplied in serum-free culture medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Major vault protein (MVP) mediates responses of cells to stress and might play a role in multidrug resistance. It has been shown to be overexpressed in drug-resistant cancer cells.

Safety & Documentation

Safety Information

WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Peer-Reviewed Papers
15

References

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