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M7397 Sigma-Aldrich

L-(−)-Malic acid

BioReagent, suitable for cell culture, suitable for insect cell culture

Synonym: (S)-(−)-2-Hydroxysuccinic acid, L-Hydroxybutanedioic acid

  • CAS Number 97-67-6

  • Linear Formula HO2CCH2CH(OH)CO2H

  • Molecular Weight 134.09

  •  Beilstein/REAXYS Number 1723541

  •  EC Number 202-601-5

  •  MDL number MFCD00064213

  •  PubChem Substance ID 24897161

  •  NACRES NA.75

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Properties

Related Categories Asymmetric Synthesis, Cell Biology, Cell Culture, Chemical Synthesis, Chiral Resolution Reagents,
product line   BioReagent
assay   ≥95% (titration)
application(s)   cell culture | insect: suitable
  cell culture | mammalian: suitable
mp   101-103 °C (lit.)
SMILES string   O[C@@H](CC(O)=O)C(O)=O
InChI   1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChI key   BJEPYKJPYRNKOW-REOHCLBHSA-N

Description

General description

Malic acid is used as a component of insect tissue culture. It is also useful as an acidulant in soft drinks, jams, fruit and vegetable juices.

Application

Malic acid has been used:
• to induce basal respiration in mitochondrial cell culture
• to measure the mitochondrial ETC (electron transport chain) activity
• as a component of mitochondrial substrate stock

Packaging

25, 100, 500 g in poly bottle

Biochem/physiol Actions

Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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