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M8449 Sigma-Aldrich

MAN-5 Glycan

≥90% (HPLC)

Synonym: (Man)5(GlcNAc)2, Mannopentaose-di-(N-acetyl-D-glucosamine), Oligomannose-5 glycan

  • CAS Number 66091-47-2

  • Empirical Formula (Hill Notation) C46H78N2O36

  • Molecular Weight 1235.10

  •  MDL number MFCD00467030

  •  PubChem Substance ID 329818060

  •  NACRES NA.25

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Properties

Quality Level   200
assay   ≥90% (HPLC)
storage temp.   −20°C
SMILES string   CC(=O)NC(C=O)C(O)C(OC1OC(CO)C(OC2OC(COC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(OC5OC(CO)C(O)C(O)C5O)C3O)C(O)C(OC6OC(CO)C(O)C(O)C6O)C2O)C(O)C1NC(C)=O)C(O)CO
InChI   1S/C46H78N2O36/c1-11(55)47-13(3-49)22(58)37(14(57)4-50)81-41-21(48-12(2)56)28(64)38(18(8-54)78-41)82-46-36(72)40(84-45-34(70)31(67)25(61)17(7-53)77-45)27(63)20(80-46)10-74-43-35(71)39(83-44-33(69)30(66)24(60)16(6-52)76-44)26(62)19(79-43)9-73-42-32(68)29(65)23(59)15(5-51)75-42/h3,13-46,50-54,57-72H,4-10H2,1-2H3,(H,47,55)(H,48,56)
InChI key   KIAGZJJOMMNKBW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Antibodies bearing high levels of N-linked mannose-5 glycan (Man-5) have been found to exhibit enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) when compared to antibodies with fucosylated complex or hybrid glycans.

Antibodies carrying high levels of N-linked mannose-5 glycan (Man5) possesses increased antibody-dependent cell-mediated cytotoxicity (ADCC) than antibodies with fucosylated complex or hybrid glycans.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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