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M9020 Sigma-Aldrich

Mecamylamine hydrochloride

Synonym: 2-(Methylamino)isocamphane hydrochloride, Inversine, N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

  • CAS Number 826-39-1

  • Empirical Formula (Hill Notation) C11H21N · HCl

  • Molecular Weight 203.75

  •  EC Number 212-555-8

  •  MDL number MFCD00151462

  •  PubChem Substance ID 24277851

  •  NACRES NA.77

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Properties

Related Categories Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   PKVZBNCYEICAQP-CIISUUNXSA-N
Quality Level   200
solubility   ethanol: 122 mg/mL
  H2O: 47 mg/mL
  isopropanol: 476 mg/mL
  glycerol: 95 mg/mL
originator   AstraZeneca
Gene Information   human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

Description

Application

Mecamylamine hydrochloride has been used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input. It has also been used as a non-selective nicotinic acetyl choline receptor blocker in aortic body neurons and in MLO-Y4 cells.

Packaging

5, 25, 100 mg in glass bottle

Biochem/physiol Actions

Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Caution

Solutions are stable to autoclaving.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
RB6900000
Protocols & Articles
Peer-Reviewed Papers
15

References

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