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M9695 Sigma-Aldrich

Matrix Metalloproteinase-12, Catalytic Domain human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: MMP-12, Macrophage Elastase

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   buffered aqueous glycerol solution
mol wt   calculated mol wt 20.3 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... MMP12(4321)

Description

General description

Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.

Biochem/physiol Actions

MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.

Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.

MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.

Unit Definition

One unit equals 100 pmol/min at 37 °C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.

Physical form

Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5.

Legal Information

Brij is a registered trademark of Croda International PLC

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Hazard statements 
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
2

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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