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MAK202 Sigma-Aldrich

Cathepsin S Inhibitor Screening Kit

Sufficient for 100 Fluorometric tests

Synonym: CTSS Inhibitor Assay Kit

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Description

General description

Cathepsin S (CTSS; EC 3.4.22.27) is a lysosomal cysteine proteinase involved in the degradation of proteins to peptides required for the presentation of MHC class II molecules.1 It is associated with pathological conditions such as atherosclerosis, coronary heart disease, cancer, and insulin resistance.

Suitability

Suitable for the screening of inhibitors of Cathepsin S.

Principle

The Cathepsin S Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSS. CTSS activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/ λem = 505 nm), proportional to the enzymatic activity present.

Kit component only

Description

Product #

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CTSS Reaction Buffer    
Cathepsin S, human    
CTSS Substrate, Z-VVR-AFC, 10 mM    
CTSS Inhibitor Z-FF-FMK, 1 mM    
Safety & Documentation

Safety Information

Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
Protocols & Articles
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