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MAK203 Sigma-Aldrich

DPP4 INHIBITOR SCREENING KIT

Sufficient for 100 Fluorometric tests

Synonym: Adenosine Deaminase Complexing Protein-2 Inhibitor Screening Kit, CD26 Inhibitor Screening Kit, Dipeptidyl-Peptidase 4 Inhibitor Screening Kit

  •  NACRES NA.25

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Properties

Related Categories Assay Kits by Specialty Area, Cell Biology, Drug Discovery/Pharma, Endocrinology - Diabetes, Enzymatic Activity Assay Kits,
shipped in   wet ice
storage temp.   2-8°C
Gene Information   human ... DPP4(1803)
mouse ... DPP4(13482)
rat ... DPP4(25253)

Description

General description

Dipeptidyl-peptidase 4 (DPP4; CD26; adenosine deaminase complexing protein-2) is a membrane glycoprotein with serine exopeptidase activity that cleaves X-proline dipeptides from the N-terminus of polypeptides. Inhibitors of DPP4 inhibit the degradation of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 by DPP4 and have emerged as oral anti-diabetic agents.

Suitability

Suitable for the screening of inhibitors of DPP4.

Principle

The DPP4 Inhibitor Screening Kit is a simple assay suitable for high-throughput screening of potential DPP4 inhibitors. DPP4 activity is measured by cleaving the substrate to yield a fluorescent product (λex = 360/λem = 460 nm), proportional to the enzymatic activity present. The effectiveness of the test inhibitors may be compared with the DPP4 inhibitor (sitagliptin) provided as a control.

Kit component only

Description

Product #

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DPP4 Assay Buffer    
DPP4 Substrate    
DPP4 Enzyme    
DPP4 Inhibitor, Sitagliptin    
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles
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