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N0665 Sigma-Aldrich

NDSB 211

≥98% (TLC)

Synonym: 3-[Dimethyl-(2-hydroxyethyl)ammonio]-1-propanesulfonate, Dimethyl(2-hydroxyethyl)(3-sulfopropyl)ammonium hydroxide inner salt, Dimethyl-2-hydroxyethylammoniumpropane sulfonate

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Properties

Related Categories Biochemicals and Reagents, Detergents, Non-Detergents Sulfobetaines (NDSB) More...
Quality Level   200
description   zwitterionic
assay   ≥98% (TLC)
form   solid
mol wt   211.28 g/mol
application(s)   DNA extraction: suitable
color   white
solubility   methanol: 5 mg/mL, clear, colorless
SMILES string   OCC[N+](C)(C)CCCS([O-])(=O)=O
InChI   1S/C7H17NO4S/c1-8(2,5-6-9)4-3-7-13(10,11)12/h9H,3-7H2,1-2H3
InChI key   CNXPCGBLGHKAIL-UHFFFAOYSA-N

Description

General description

Dimethyl-2-hydroxyethylammoniumpropane sulfonate, or NDSB 211, is a nondetergent-sulfobetain. It is zwitterionic over a wide pH range, easily removed by dialysis and shows no significant absorption in the near UV range.

Application

NDSB 211 has been used in a study to assess halophilic protein stabilization by the mild solubilizing agents nondetergent sulfobetaines. It has also been used in a study to investigate an alternative strategy for crystallizing macromolecules.

Non-detergent sulfobetaine is a compound used for non-denaturing protien purification. Increases the extraction yield of membrane, nuclear and cytoskeletal associated proteins. Zwitterionic over a wide pH range, easily removed by dialysis and no significant absorption in the near UV range. Specific applications include microsomal protein extraction, nuclear protein recovery, precipitation reduction in IEF, and membrane-bound protease purification.

Packaging

1, 5 g in poly bottle

Other Notes

This product is non-micelle forming.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3261 8 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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