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N0790 Sigma-Aldrich

NDSB 221

≥97% (TLC)

Synonym: 3-(1-Methylpiperidinio)-1-propanesulfonate, 3-(1-Methylpiperidinium)-1-propane sulfonate

  • CAS Number 160788-56-7

  • Empirical Formula (Hill Notation) C9H19NO3S

  • Molecular Weight 221.32

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Properties

Related Categories Biochemicals and Reagents, Detergents, Non-Detergents Sulfobetaines (NDSB) More...
description   zwitterionic
assay   ≥97% (TLC)
form   solid
color   white
solubility   H2O: 50 mg/mL, clear, colorless

Description

General description

NDSB 221 is a nondetergent sulfobetaine that has been found to improve unfolding reversibility.

Application

NDSB 221 has been used in a study to identify a novel ligand binding site in phosphoserine phosphatase from Thermococcus onnurineus. It has also been used in a study to investigate its effects on acidic fibroblast growth factor (aFGF).

Non-detergent sulfobetaine is a compound used for non-denaturing protien purification. Increases the extraction yield of membrane, nuclear and cytoskeletal associated proteins. Zwitterionic over a wide pH range, easily removed by dialysis and no significant absorption in the near UV range. Specific applications include microsomal protein extraction, nuclear protein recovery, precipitation reduction in IEF, and membrane-bound protease purification. The typical usage concentration is 0.5 - 2.0 M.

Packaging

5, 25 g in poly bottle

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1759 8 / PGII
WGK Germany 
1

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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