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N1016 Sigma-Aldrich

Nimesulide

Synonym: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

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Description

General description

Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) belongs to the sulfonanilide class.

Application

Nimesulide has been used as a component in the reaction mixture to determine the activity of cyclooxygenase (COX) in spleen of chickens.

Biochem/physiol Actions

Nimesulide can be used as a substitute to other nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain and inflammation of osteoarthritis for a short period. It can perform anti-inflammatory, analgesic and antipyretic activities.

Highly selective cyclooxygenase-2 inhibitor.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
PB0970000

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

Peer-Reviewed Papers
15

References

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