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N1628 Sigma-Aldrich

Novobiocin sodium salt

≥90% (HPLC)

  • CAS Number 1476-53-5

  • Empirical Formula (Hill Notation) C31H35N2NaO11

  • Molecular Weight 634.61

  •  Beilstein/REAXYS Number 3892910

  •  EC Number 216-023-6

  •  PubChem Substance ID 24897508

  •  NACRES NA.85

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,
assay   ≥90% (HPLC)
solubility   H2O: soluble 50 mg/mL
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C
SMILES string   [Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C
InChI   1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
InChI key   AXOUUAINTJNFRS-UHFFFAOYSA-N

Description

General description

Chemical structure: coumarin-glycoside

Application

Novobiocin, an inhibitor of Hsp90, is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA.

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Packaging

1, 5, 25, 100 g in glass bottle

Biochem/physiol Actions

Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

Other Notes

Stored in frozen aliquots,Keep container tightly closed in a dry and well-ventilated place.Light sensitive

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
RD5425000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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pHast Pack
Protocols & Articles

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Peer-Reviewed Papers
15

References

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