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N2286 Sigma-Aldrich

Nonactin

from Streptomyces griseus, ≥98% (function tested, HPLC)

Synonym: Ammonium ionophore

  • CAS Number 6833-84-7

  • Empirical Formula (Hill Notation) C40H64O12

  • Molecular Weight 736.93

  •  Beilstein/REAXYS Number 76434

  •  EC Number 229-911-3

  •  PubChem Substance ID 24897566

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action,
Quality Level   PREMIUM
biological source   Streptomyces griseus
description   Natural macrotetrolide, may contain homologues (like monactin and dinactin)
assay   ≥98% (function tested, HPLC)
quality   function tested (ion specific electrode for ammonium ions)
solubility   chloroform: soluble 10 mg/mL
Mode of action   DNA synthesis | interferes
  cell membrane | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

General description

Chemical structure: macrolide

Application

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation .

Packaging

10, 100 mg in glass bottle

Biochem/physiol Actions

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, and to inhibit surface expression of certain heat shock proteins (HSP60) .

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
RH1685000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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