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N3510 Sigma-Aldrich

Niclosamide

Synonym: 2′,5-Dichloro-4′-nitrosalicylanilide

  • CAS Number 50-65-7

  • Empirical Formula (Hill Notation) C13H8Cl2N2O4

  • Molecular Weight 327.12

  •  Beilstein/REAXYS Number 2820605

  •  EC Number 200-056-8

  •  MDL number MFCD00057597

  •  PubChem Substance ID 24278585

  •  NACRES NA.85

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Mechanism of Action, Antiparasitic / Antiprotozoal / Anthelminthic,
Quality Level   200
Mode of action   enzyme | inhibits
antibiotic activity spectrum   parasites
SMILES string   Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O
InChI   1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChI key   RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Description

Application

Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells.

Biochem/physiol Actions

Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ– regulated genes in AML cells.

Other Notes

50g,250g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
VN8400000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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