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N3908 Sigma-Aldrich

Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: NGFR Antibody - Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit, Ngfr Antibody

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Apoptosis, Antibodies for Cell Biology,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry (frozen sections): 1:10,000 using rat brain
  indirect immunofluorescence: 1:500 using NGF-treated PC12 cells
  microarray: suitable
  western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells
species reactivity   rat
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   P07174
Gene Information   rat ... Ngfr(24596)

Description

General description

Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.

Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.

Immunogen

synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.

Application

Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:
• immunoprecipitation
• immunocytochemistry
• immunohistochemistry
• immunoblotting

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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N6163 Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody produced in goat, affinity isolated antibody, lyophilized powder
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