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N5536 Sigma-Aldrich

Nefazodone hydrochloride

≥98% (HPLC), solid

Synonym: 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride, BMY-13754, MJ-13754-1, Serzone

  • CAS Number 82752-99-6

  • Empirical Formula (Hill Notation) C25H32ClN5O2 · HCl

  • Molecular Weight 506.47

  •  MDL number MFCD00935760

  •  PubChem Substance ID 24724551

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,
assay   ≥98% (HPLC)
form   solid
color   white
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble
originator   Bristol-Myers Squibb
SMILES string   O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.Cl
InChI   1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H
InChI key   DYCKFEBIOUQECE-UHFFFAOYSA-N
Gene Information   human ... HTR2A(3356), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Separation

Peer-Reviewed Papers
15

References

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