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N7537 Sigma-Aldrich

NSC 663284

≥98% (HPLC), solid

Synonym: 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione

  • CAS Number 383907-43-5

  • Empirical Formula (Hill Notation) C15H16ClN3O3

  • Molecular Weight 321.76

  •  MDL number MFCD08276924

  •  PubChem Substance ID 24724556

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cdc25 dual specificity phosphatase (Cdc25), Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   red
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble
storage temp.   2-8°C
SMILES string   ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
InChI   1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChI key   BMKPVDQDJQWBPD-UHFFFAOYSA-N
Gene Information   human ... CDC25B(994), DUSP3(1845), PTPN1(5770)

Description

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
470.1 °F
Flash Point(C) 
243.4 °C

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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