• USA Home
  • N7758 - Naloxone hydrochloride dihydrate

EMAIL THIS PAGE TO A FRIEND
N7758 Sigma-Aldrich

Naloxone hydrochloride dihydrate

≥98% (TLC and titration), powder

  • CAS Number 51481-60-8

  • Empirical Formula (Hill Notation) C19H21NO4 · HCl · 2H2O

  • Molecular Weight 399.87

  •  Beilstein/REAXYS Number 6260807

  •  MDL number MFCD00150901

  •  PubChem Substance ID 24278050

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   TXMZWEASFRBVKY-IOQDSZRYSA-N
assay   ≥98% (TLC and titration)
form   powder
optical activity   [α]25/D −178.6°, c = 2.5 in H2O(lit.)
color   white to off-white
solubility   ethanol: 3.3 mg/mL
  H2O: 50 mg/mL
storage temp.   2-8°C
Gene Information   human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Description

Application

Naloxone hydrochloride dihydrate has been used in:
• isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
• as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
• as a reference neutral antagonist to define the maximum effect (Emax) of the system

Packaging

1, 5 g in poly bottle

250 mg in poly bottle

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Light sensitive.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

???PDP_SDS_LOT_NUMBER_ERROR_MSG???

Certificate of Origin

???PDP_SDS_LOT_NUMBER_ERROR_MSG???
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?