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  • N8539 - Anti-NDRG1 (C-terminal) antibody produced in rabbit

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N8539 Sigma-Aldrich

Anti-NDRG1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-CAP43, Anti-CMT4D, Anti-DRG1, Anti-GC4, Anti-HMSNL, Anti-N-myc downstream regulated 1, Anti-NDR1 (differentiation-related gene 1 protein), Anti-NMSL, Anti-PROXY1 (protein regulated by oxygen 1), Anti-RIT42, Anti-RTP (reducing agents and tunicamycin-responsive protein), Anti-TARG1, TDD5

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Cell Stress, Antibodies to Oxidative Stress Proteins,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunoprecipitation (IP): 5-10 μg using lysates of HeLa cells
  western blot: 1-2 μg/mL using whole extract of mouse 3T3 and rat NRK cells
species reactivity   mouse, rat, human
mol wt   antigen ~43 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
packaging   antibody small pack of 25 μL
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
concentration   ~1.0 mg/mL
UniProt accession no.   Q92597
Gene Information   human ... NDRG1(10397)

Description

General description

N-myc downstream regulated 1 (NDRG1) is a member of the N-myc downregulated gene family that belongs to the alpha/beta hydrolase superfamily. In humans, this protein is mainly expressed in epithelial cells.

Application

Anti-NDRG1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

The cytoplasmic protein encoded by N-myc downstream regulated 1 (NDRG1) gene participates in stress responses, hormone responses, cell growth and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. NDRG1 is a Rab4a effector, that participates in vesicular recycling of E-cadherin. It plays a key role in peripheral nervous system myelination. It also helps to modulate lipid fate in breast cancer cells.

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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