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N9653 Sigma

Netropsin dihydrochloride

from Streptomyces netropsis, ≥98% (HPLC and TLC), powder

Synonym: Congocidin, Sinanomycin

  • CAS Number 18133-22-7

  • Empirical Formula (Hill Notation) C18H26N10O3 · 2HCl

  • Molecular Weight 503.39

  •  PubChem Substance ID 24897909

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
biological source   Streptomyces netropsis
InChI Key   SDRHUASONSRLFR-UHFFFAOYSA-N
assay   ≥98% (HPLC and TLC)
form   powder
color   faintly yellow
solubility   H2O: 1 mg/mL
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  viruses
storage temp.   −20°C

Description

Caution

Protect from light.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
DW2973000

Documents

Certificate of Analysis

Certificate of Origin


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Biomedical Applications
Protocols & Articles
Peer-Reviewed Papers
15

References

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