O1383 Sigma-Aldrich

Oleic acid

suitable for cell culture, BioReagent

Synonym: cis-9-Octadecenoic acid, Elainic acid

  • CAS Number 112-80-1

  • Linear Formula CH3(CH2)7CH=CH(CH2)7COOH

  • Molecular Weight 282.46

  •  Beilstein Registry Number 1726542

  •  EC Number 204-007-1

  •  MDL number MFCD00064242

  •  PubChem Substance ID 24897941



Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Carthamus tinctorius (Safflower oil), Cell Biology,
vapor pressure   1 mmHg ( 176 °C)
product line   BioReagent
assay   ≥99% (GC)
form   viscous liquid
refractive index   n20/D 1.459(lit.)
bp   194-195 °C/1.2 mmHg(lit.)
mp   13-14 °C (lit.)
solubility   ethanol: soluble
density   0.89 g/mL at 25 °C(lit.)
  0.89 g/mL at 25 °C(lit.)
suitability   suitable for cell culture
storage temp.   −20°C
Gene Information   human ... SOAT1(6646), SOAT2(8435)


Biochem/physiol Actions

Activates protein kinase C in hepatocytes.

Uncouples oxidative phosphorylation. Inhibits 2,4-dinitrophenol−stimulated ATPase. Action reversed by adding serum albumin.


Unsaturated fatty acids are subject to oxidation and peroxidation. Consider complexed fatty acid supplements.


1, 5, 25 g in ampule

Sealed ampule.


Oleic acid has been used:
• in fatty acid oxidation rate experiments in myotubes and in Sirt1 enzyme assay
• to determine quantitatively its effect on lipid droplets by optical diffraction tomography
• as a fatty acid source in the medium for primary hepatocyte culture

General description

Oleic acid is a mono-unsaturated omega-9 fatty acid created by dehydrogenation of stearic acid. It is then further dehydrogenated and elongated to create members of the n-9 family of fatty acids. Oleic acid is not an essential fatty acid (EFA); however, providing it to cells in culture reduces energy demand.

Oleic acid mediates complete oxidation of fatty acid in sirtuin1- proliferator-activated receptor γ coactivator−1α (SIRT1-PGC-1α) signalling pathway. Oleic acid shows anti-inflammatory properties related to atherosclerosis and insulin resistant state. Oleic acid inhibits permeability in gap junctions and promotes glucose uptake in astrocytes. Oleic acid aids in neural cell proliferation by increasing glucose uptake and by protein kinase C (PKC) activation. Oleic acid is essential for axonal growth and neuronal clustering.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
>235.4 °F
Flash Point(C) 
>113 °C

Request a Serum Sample

Milli-Q® Water Purification Solutions
Protocols & Articles


Lipid Induced Insulin Resistance

Obesity is a well-established risk factor for the development of insulin resistance. Obesity is associated with the increased deposition of lipids in non-adipose tissue with subsequent decreases in i...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 9
Keywords: Angiogenesis, Antivirals, Apoptosis, Biological processes, Cardiovascular, Catalog, Catalysis, Cell culture, Cell proliferation, Deposition, Diabetes, Events, Gene expression, Growth factors, Hormones, Inflammation, Metabolism, Metabolites, Obesity, Phosphorylations, Physiological Processes, Reductions, Transcription, Transduction, Type

Related Content

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers


Related Products


Product #


Add to Cart

L9655 Linoleic Acid-Oleic Acid-Albumin, 100x, liquid, sterile-filtered, BioReagent, suitable for cell culture
O3008 Oleic Acid-Albumin from bovine serum, liquid, sterile-filtered, BioReagent, suitable for cell culture

related product

Product #


Add to Cart

43917 SnapIT Ampule Opener, large, for 5-10ml, 10-15ml, 20-25ml ampoules
06693 Timestrip Plus -20 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?