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O2375 Sigma-Aldrich

L-Ornithine monohydrochloride

≥99%

Synonym: (S)-2,5-Diaminopentanoic acid monohydrochloride

  • CAS Number 3184-13-2

  • Empirical Formula (Hill Notation) C5H12N2O2 · HCl

  • Molecular Weight 168.62

  •  Beilstein/REAXYS Number 3625847

  •  EC Number 221-678-6

  •  MDL number MFCD00064562

  •  PubChem Substance ID 24897960

  •  NACRES NA.26

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Properties

Related Categories Amino Acid, Amino acids, Cell Biology, Chemical Biology, Chemical Synthesis,
Quality Level   200
assay   ≥99%
form   powder
application(s)   cell analysis: suitable
impurities   ammonia and citrulline, essentially free
color   white
SMILES string   Cl.NCCC[C@H](N)C(O)=O
InChI   1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
InChI key   GGTYBZJRPHEQDG-WCCKRBBISA-N

Description

Application

L-Ornithine monohydrochloride has been used to study the blocking effect of L-ornithine on the transport system that carries L-arginine for the overproduction of nitric oxide during lipopolysaccharide induced endotoxemia in rat model. It has also been used in decarboxylation test of amino acids.

Packaging

1 kg in poly bottle

10 mg in glass bottle

5, 25, 100 g in poly bottle

Biochem/physiol Actions

L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle. In mammals, ornithine serves as a precursor for polyamines and proline biosynthesis. Spermine synthesized from ornithine, is an abundant polyamine observed in tumors such as breast carcinomas. Administration of L-ornithine is known to improve subjective index of sleep quality. L-ornithine reduces the cortisol/DHEA-S (dehydroepiandrosterone) ratio, that is associated with stress. In mice, L-ornithine is found to affect the levels of plasma growth hormone, corticosterone and melatonin levels in mice.

Other Notes

Product of arginine degradation by arginase

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. O2375.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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