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O2378 Sigma-Aldrich

Oxymetazoline hydrochloride

≥99%, solid

Synonym: 2-(3-Hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline hydrochloride

  • CAS Number 2315-02-8

  • Empirical Formula (Hill Notation) C16H24N2O · HCl

  • Molecular Weight 296.84

  •  EC Number 219-015-0

  •  MDL number MFCD00058147

  •  PubChem Substance ID 24277792

  •  NACRES NA.77

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Properties

Related Categories Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
Quality Level   100
assay   ≥99%
form   solid
solubility   H2O: soluble
  alcohol: soluble
originator   Schering Plough
storage temp.   room temp
SMILES string   Cl.Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C
InChI   1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H
InChI key   BEEDODBODQVSIM-UHFFFAOYSA-N
Gene Information   human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), HTR1A(3350), HTR1B(3351), HTR1D(3352)

Description

Packaging

5, 25 g in poly bottle

Biochem/physiol Actions

Oxymetazoline hydrochloride is a partial α2A-adrenoceptor agonist; agonist at 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors. It is a mixed agonist-antagonist at 5-HT1C serotonin receptors.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Alpha 2 Adrenoreceptor Modulators

α2-Adrenoceptors are widely distributed and are activated by norepinephrine (A7257, A0937), released from sympathetic nerve terminals or by epinephrine (E4250, E4375), released from the adrenal medul...
Keywords: Analgesics, Atomic absorption spectroscopy, Cardiovascular, Eliminations, Gene expression, Genetic, Neurotransmission, Neurotransmitters, Transduction

Peer-Reviewed Papers
15

References

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