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O2751 Sigma-Aldrich

Sodium oxamate

≥98%

Synonym: Aminooxoacetic acid sodium salt, Oxalic acid monoamide sodium salt, Oxamic acid sodium salt

  • CAS Number 565-73-1

  • Linear Formula NH2COCOONa

  • Molecular Weight 111.03

  •  Beilstein/REAXYS Number 6538153

  •  EC Number 209-290-5

  •  MDL number MFCD00044553

  •  PubChem Substance ID 24278607

  •  NACRES NA.77

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Properties

Related Categories Aerobic Glycolysis (the Warburg Effect), Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Cell Biology,
Quality Level   200
biological source   synthetic (organic)
assay   ≥98%
form   powder
mp   300 °C
solubility   water: 50 mg/mL, clear, colorless
SMILES string   [Na+].NC(=O)C([O-])=O
InChI   1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1
InChI key   RQVZIJIQDCGIKI-UHFFFAOYSA-M

Description

Application

Sodium oxamate has been used:
• as one of the variable in flow injection analysis
• in in vitro angiogenesis assay
• to confirm the stimulatory role of stearic acid on lactate dehydrogenase mediated lactate production

Packaging

5, 25, 100 g in poly bottle

Biochem/physiol Actions

Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes.

Structural analog of pyruvate, inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway. Binding studies with lactate dehydrogenase; Mechanism of inhibition of mitochondrial pyruvate metabolism

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
BioFiles v7 n4
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, Phosphorylations, Transcription

Peer-Reviewed Papers
15

References

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