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O3639 Sigma

Ondansetron hydrochloride dihydrate

≥98% (HPLC), powder

Synonym: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride, GR 38032F

  • CAS Number 103639-04-9

  • Empirical Formula (Hill Notation) C18H19N3O · HCl · 2H2O

  • Molecular Weight 365.85

  •  MDL number MFCD00374371

  •  PubChem Substance ID 329818907

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Properties

Related Categories Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   VRSLTNZJOUZKLX-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white
solubility   H2O: >5 mg/mL
storage temp.   −20°C

Description

Biochem/physiol Actions

5-HT3 serotonin receptor antagonist

Ondansetron, (3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl] 1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dehydrate acts as a selective 5-hydroxytryptamine type 3 (5-HT3) serotonin receptor antagonist. It is used as an antiemetic to control nausea and vomiting associated with chemotherapy and radiotherapy.

Packaging

10, 50 mg in glass bottle

Application

Ondansetron hydrochloride dihydrate has been used as a 5-HT3 antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT3 protein.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
FE6375500

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles
Peer-Reviewed Papers
15

References

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